Since 2017 the Guardians and Twins have met 144 times in the regular season, with the Guardians holding a 82–62 edge in the series.
Most recently the Twins won 6–2 on September 21, 2025.
Right now the Guardians are 85–77 and the Twins are 77–85, with the Twins at 17 days since a win against the Guardians' 2.
| Season | Wins |
|---|---|
| 2025 | Guardians 9, Twins 4 |
| 2024 | Guardians 10, Twins 3 |
| 2023 | Guardians 7, Twins 6 |
| 2022 | Guardians 13, Twins 6 |
| 2021 | Guardians 8, Twins 11 |
| 2020 | Guardians 3, Twins 7 |
| 2019 | Guardians 10, Twins 9 |
| 2018 | Guardians 10, Twins 9 |
| 2017 | Guardians 12, Twins 7 |
| Date | Host | Winner | Score |
|---|---|---|---|
| Sun, Sep 21 2025 | Twins home | Twins | 6–2 |
| Sat, Sep 20 2025 | Twins home | Guardians | 8–0 |
| Sat, Sep 20 2025 | Twins home | Guardians | 6–0 |
| Fri, Sep 19 2025 | Twins home | Guardians | 6–2 |
| Sun, Aug 3 2025 | Guardians home | Twins | 5–4 |
| Sat, Aug 2 2025 | Guardians home | Guardians | 5–4 |
| Fri, Aug 1 2025 | Guardians home | Guardians | 3–2 |
| Wed, May 21 2025 | Twins home | Guardians | 5–1 |
| Mon, May 19 2025 | Twins home | Twins | 6–5 |
| Thu, May 1 2025 | Guardians home | Guardians | 4–3 |
| Wed, Apr 30 2025 | Guardians home | Guardians | 4–2 |
| Tue, Apr 29 2025 | Guardians home | Guardians | 2–1 |
| Mon, Apr 28 2025 | Guardians home | Twins | 11–1 |
| Thu, Sep 19 2024 | Guardians home | Guardians | 3–2 |
| Wed, Sep 18 2024 | Guardians home | Guardians | 5–4 |
Full schedules and drought counters: Cleveland Guardians and Minnesota Twins.
White Sox vs Guardians, White Sox vs Tigers, White Sox vs Royals, White Sox vs Twins, Guardians vs Tigers, Guardians vs Royals, Tigers vs Royals, Tigers vs Twins, Royals vs Twins.