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49ers vs Cardinals

Since 1968 the 49ers and Cardinals have met 66 times, with 49ers holding a 38–28 edge in the series.

The series

Most recently the 49ers won 36–30 on September 27, 2026.

Right now the 49ers are 5–0 and the Cardinals are 1–4, with Cardinals at 31 days since a win against 49ers's 3.

San Francisco 49ers against Arizona Cardinals
DateHostWinnerScore
Sun, Sep 27 202649ers home49ers36–30
Sun, Nov 16 2025Cardinals home49ers41–22
Sun, Sep 21 202549ers home49ers16–15
Sun, Jan 5 2025Cardinals homeCardinals47–24
Sun, Oct 6 202449ers homeCardinals24–23
Sun, Dec 17 2023Cardinals home49ers45–29
Sun, Oct 1 202349ers home49ers35–16
Sun, Jan 8 202349ers home49ers38–13
Mon, Nov 21 2022Neutral site49ers38–10
Sun, Nov 7 202149ers homeCardinals31–17
Sun, Oct 10 2021Cardinals homeCardinals17–10
Sat, Dec 26 2020Cardinals home49ers20–12
Sun, Sep 13 202049ers homeCardinals24–20
Sun, Nov 17 201949ers home49ers36–26
Thu, Oct 31 2019Cardinals home49ers28–25
Sun, Oct 28 2018Cardinals homeCardinals18–15
Sun, Oct 7 201849ers homeCardinals28–18
Sun, Nov 5 201749ers homeCardinals20–10
Sun, Oct 1 2017Cardinals homeCardinals18–15
Sun, Nov 13 2016Cardinals homeCardinals23–20
Thu, Oct 6 201649ers homeCardinals33–21
Sun, Nov 29 201549ers homeCardinals19–13
Sun, Sep 27 2015Cardinals homeCardinals47–7
Sun, Dec 28 201449ers home49ers20–17
Sun, Sep 21 2014Cardinals homeCardinals23–14
Sun, Dec 29 2013Cardinals home49ers23–20
Sun, Oct 13 201349ers home49ers32–20
Sun, Dec 30 201249ers home49ers27–13
Mon, Oct 29 2012Cardinals home49ers24–3
Sun, Dec 11 2011Cardinals homeCardinals21–19
Sun, Nov 20 201149ers home49ers23–7
Sun, Jan 2 201149ers home49ers38–7
Mon, Nov 29 2010Cardinals home49ers27–6
Mon, Dec 14 200949ers home49ers24–9
Sun, Sep 13 2009Cardinals home49ers20–16
Mon, Nov 10 2008Cardinals homeCardinals29–24
Sun, Sep 7 200849ers homeCardinals23–13
Sun, Nov 25 2007Cardinals home49ers37–31
Mon, Sep 10 200749ers home49ers20–17
Sun, Dec 24 200649ers homeCardinals26–20
Sun, Sep 10 2006Cardinals homeCardinals34–27
Sun, Dec 4 200549ers homeCardinals17–10
Sun, Oct 2 2005Neutral siteCardinals31–14
Sun, Dec 12 2004Cardinals home49ers31–28
Sun, Oct 10 200449ers home49ers31–28
Sun, Dec 7 200349ers home49ers50–14
Sun, Oct 26 2003Cardinals homeCardinals16–13
Sat, Dec 21 2002Cardinals home49ers17–14
Sun, Oct 27 200249ers home49ers38–28
Sun, Oct 1 200049ers home49ers27–20
Mon, Sep 27 1999Cardinals home49ers24–10
Sun, Oct 24 199349ers home49ers28–14
Sun, Nov 1 1992Cardinals homeCardinals24–14
Sun, Nov 17 199149ers home49ers14–10
Sun, Nov 6 1988Cardinals homeCardinals24–23
Sun, Oct 18 198749ers home49ers34–28
Sun, Nov 9 198649ers home49ers43–17
Sun, Sep 18 1983Cardinals home49ers42–27
Sun, Nov 21 1982Cardinals home49ers31–20
Sun, Sep 14 198049ers home49ers24–21
Sun, Dec 2 1979Cardinals homeCardinals13–10
Sun, Nov 12 197849ers homeCardinals16–10
Sun, Oct 31 1976Cardinals homeCardinals23–20
Sun, Oct 6 197449ers homeCardinals34–9
Sun, Oct 24 1971Cardinals home49ers26–14
Sun, Sep 22 196849ers home49ers35–17

Full schedules and drought counters: San Francisco 49ers and Arizona Cardinals.

The rest of the division

Cardinals vs Rams, Cardinals vs Seahawks, Rams vs 49ers, Rams vs Seahawks, 49ers vs Seahawks.