Since the 2017–18 season the Panthers and Sabres have met 31 times in the regular season, with the Panthers holding a 21–10 edge in the series.
Most recently the Sabres won 5–3 on October 12, 2026.
Right now the Panthers are 3–2–2 and the Sabres are 3–3–1, with the Sabres at 2 days since a win against the Panthers' 1.
| Season | Wins |
|---|---|
| 2026–27 | Panthers 0, Sabres 1 |
| 2025–26 | Panthers 1, Sabres 3 |
| 2024–25 | Panthers 3, Sabres 1 |
| 2023–24 | Panthers 3, Sabres 0 |
| 2022–23 | Panthers 3, Sabres 1 |
| 2021–22 | Panthers 4, Sabres 0 |
| 2019–20 | Panthers 0, Sabres 3 |
| 2018–19 | Panthers 3, Sabres 1 |
| 2017–18 | Panthers 4, Sabres 0 |
| Date | Host | Winner | Score |
|---|---|---|---|
| October 12, 2026 | Sabres home | Sabres | 5–3 |
| February 27, 2026 | Panthers home | Sabres | 3–2 |
| February 2, 2026 | Panthers home | Sabres | 5–3 |
| January 12, 2026 | Sabres home | Panthers | 4–3 |
| October 18, 2025 | Sabres home | Sabres | 3–0 |
| April 12, 2025 | Panthers home | Panthers | 3–2 |
| March 8, 2025 | Panthers home | Panthers | 4–0 |
| October 28, 2024 | Sabres home | Panthers | 5–2 |
| October 12, 2024 | Sabres home | Sabres | 5–2 |
| April 13, 2024 | Panthers home | Panthers | 3–2 |
| February 27, 2024 | Panthers home | Panthers | 3–2 |
| February 15, 2024 | Sabres home | Panthers | 4–0 |
| April 4, 2023 | Panthers home | Panthers | 2–1 |
| February 24, 2023 | Panthers home | Sabres | 3–1 |
| January 16, 2023 | Sabres home | Panthers | 4–1 |
Full schedules and drought counters: Florida Panthers and Buffalo Sabres.
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