Since the 2022 season, Mississippi Valley State and Southern have met 2 times and split them evenly at 1–1.
Most recently Mississippi Valley State won 5–0 on February 26, 2022.
Right now Mississippi Valley State is 1–38 and Southern is 42–17, with Mississippi Valley State at 240 days since a win against Southern's 164.
| Date | Site | Winner | Score |
|---|---|---|---|
| Sat, Feb 26 2022 | Neutral site | Mississippi Valley State | 5–0 |
| Fri, Feb 25 2022 | Neutral site | Southern | 7–0 |
Full schedules and drought counters: Mississippi Valley State Delta Devils and Southern Jaguars.
Mississippi Valley State vs Alabama A&M, Mississippi Valley State vs Alabama State, Mississippi Valley State vs Alcorn State, Mississippi Valley State vs Arkansas-Pine Bluff, Mississippi Valley State vs Bethune-Cookman, Mississippi Valley State vs Florida A&M, Mississippi Valley State vs Grambling, Mississippi Valley State vs Jackson State, Mississippi Valley State vs Prairie View A&M, Mississippi Valley State vs Texas Southern.
Southern vs Alabama A&M, Southern vs Alabama State, Southern vs Alcorn State, Southern vs Arkansas-Pine Bluff, Southern vs Bethune-Cookman, Southern vs Florida A&M, Southern vs Grambling, Southern vs Jackson State, Southern vs Prairie View A&M, Southern vs Texas Southern.