Since the 2017 season, Clemson and Louisville have met 13 times, with Clemson holding a 10–3 edge in the series.
Most recently Louisville won 7–6 on March 15, 2026.
Right now Clemson is 34–22 and Louisville is 44–14, with Louisville at 166 days since a win against Clemson's 156.
| Date | Site | Winner | Score |
|---|---|---|---|
| Sun, Mar 15 2026 | Clemson home | Louisville | 7–6 |
| Sat, Mar 14 2026 | Clemson home | Clemson | 4–0 |
| Fri, Mar 13 2026 | Clemson home | Clemson | 8–6 |
| Sun, Apr 28 2024 | Louisville home | Clemson | 11–5 |
| Sat, Apr 27 2024 | Louisville home | Louisville | 6–3 |
| Fri, Apr 26 2024 | Louisville home | Clemson | 6–5 |
| Sun, Mar 27 2022 | Clemson home | Louisville | 4–2 |
| Sat, Mar 26 2022 | Clemson home | Clemson | 8–0 |
| Fri, Mar 25 2022 | Clemson home | Clemson | 5–2 |
| Sun, Mar 21 2021 | Louisville home | Clemson | 4–2 |
| Sat, Mar 20 2021 | Louisville home | Clemson | 6–1 |
| Sat, Mar 20 2021 | Louisville home | Clemson | 2–1 |
| Fri, Mar 19 2021 | Louisville home | Clemson | 4–0 |
Full schedules and drought counters: Clemson Tigers and Louisville Cardinals.
Clemson vs Boston College, Clemson vs California, Clemson vs Duke, Clemson vs Florida State, Clemson vs Georgia Tech, Clemson vs NC State, Clemson vs North Carolina, Clemson vs Notre Dame, Clemson vs Pittsburgh, Clemson vs Stanford, Clemson vs Syracuse, Clemson vs Virginia, Clemson vs Virginia Tech.
Louisville vs Boston College, Louisville vs California, Louisville vs Duke, Louisville vs Florida State, Louisville vs Georgia Tech, Louisville vs NC State, Louisville vs North Carolina, Louisville vs Notre Dame, Louisville vs Pittsburgh, Louisville vs Stanford, Louisville vs Syracuse, Louisville vs Virginia, Louisville vs Virginia Tech.