Since the 2017 season, Louisville and Syracuse have met 16 times, with Louisville holding a 13–3 edge in the series.
Most recently Louisville won 13–7 on April 26, 2026.
Right now Louisville is 44–14 and Syracuse is 18–26, with Syracuse at 181 days since a win against Louisville's 166.
| Date | Site | Winner | Score |
|---|---|---|---|
| Sun, Apr 26 2026 | Louisville home | Louisville | 13–7 |
| Sat, Apr 25 2026 | Louisville home | Louisville | 5–1 |
| Fri, Apr 24 2026 | Louisville home | Louisville | 13–5 |
| Sat, Apr 1 2023 | Syracuse home | Louisville | 8–0 |
| Sat, Apr 1 2023 | Syracuse home | Louisville | 5–3 |
| Wed, May 11 2022 | Louisville home | Syracuse | 2–0 |
| Sun, Apr 17 2022 | Louisville home | Louisville | 3–2 |
| Sat, Apr 16 2022 | Louisville home | Louisville | 4–1 |
| Fri, Apr 15 2022 | Louisville home | Louisville | 8–0 |
| Sun, Mar 17 2019 | Louisville home | Syracuse | 4–2 |
| Sat, Mar 16 2019 | Louisville home | Louisville | 8–0 |
| Fri, Mar 15 2019 | Louisville home | Louisville | 4–2 |
| Wed, May 9 2018 | Louisville home | Louisville | 2–1 |
| Fri, Apr 13 2018 | Syracuse home | Syracuse | 4–3 |
| Fri, Apr 13 2018 | Syracuse home | Louisville | 3–2 |
| Fri, Mar 24 2017 | Syracuse home | Louisville | 7–4 |
Full schedules and drought counters: Louisville Cardinals and Syracuse Orange.
Louisville vs Boston College, Louisville vs California, Louisville vs Clemson, Louisville vs Duke, Louisville vs Florida State, Louisville vs Georgia Tech, Louisville vs NC State, Louisville vs North Carolina, Louisville vs Notre Dame, Louisville vs Pittsburgh, Louisville vs Stanford, Louisville vs Virginia, Louisville vs Virginia Tech.
Syracuse vs Boston College, Syracuse vs California, Syracuse vs Clemson, Syracuse vs Duke, Syracuse vs Florida State, Syracuse vs Georgia Tech, Syracuse vs NC State, Syracuse vs North Carolina, Syracuse vs Notre Dame, Syracuse vs Pittsburgh, Syracuse vs Stanford, Syracuse vs Virginia, Syracuse vs Virginia Tech.